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When your clinical trial has to Overachieve in Central and Eastern Europe, HungaroTrial is here to help. Providing services for Phase 1 through Phase 4 clinical trials in Hungary, Czech Republic, Slovakia, Romania, Serbia, Croatia, Bulgaria, Bosnia, Poland, Ukraine, Belgium and Russia, HungaroTrial is the CEE region’s leading independent CRO.

To Overachieve, your clinical trial needs the best minds from beginning to end. That’s why Hungarotrial’s full-time staff includes 12 MDs of various specialties,more than any other independent CRO in the region. And you can be assured that our experienced team has built strong relationships with the most respected Key Opinion Leaders in CEE.

Our staff’s broad medical experience means that your clinical study benefits from diverse skills and synergistic teamwork. Over the past 18 years, HungaroTrial has become well known not just for this broad expertise, but also for our deep experience in Oncology, Rheumatology, Cardiovascular diseases, PAO, CNS and some other focus therapeutic areas.

Kymeris Therapeutics (Canada) has exlusive license to a ground-breaking cell-based immunotherapeutic product for clinical development in cancer. This multivalent anti-cancer platform integrates multiple mechanisms in one modifiable platform. The product is tumor-homing, disables the local tumor defenses and expresses encoded biodrugs in the cancer - but not systemically.

*  We are seeking partners with small molecule or antibody (or any encodable peptide or protein) that would have an enabling platform compared to intravenous or intratumoral formulations.

*  We are also seeking strategic investors in the platform that has extremely high potential in future products, adaptable against almost any solid cancer.

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The platform can enable, or enhance, additional small molecule, antibody, peptide or cytokine agents.  It is a preclinical late-stage firm that has discovered and developed a First-in-Class immunotherapeutic platform based on non-pathogenic eukaryotes (nucleated cells, non-viral, non-bacterial). Our platform is original with the first scientific paper just published in November 2020 by the Journal of Immunotherapy of Cancer (BMJ), and our first scientific presentation at the 2020 Annual Meeting of the SITC where we presented recent report on a derivative that secreted human IL-15 within tumor, but devoid of serum detection of the cytokine.

The platform would be a paradigm shift from "reductive" (targeted, mono-mechanism) approaches, and can be encoded with additional molecular therapies to more comprehensively face the complex of solid cancer defenses. Encoding any biological agent (small molecule, antibody, antigen, cytokine...), could enable that agent for a wider scope of applications,  enhanced effect and much safer profile.  In addition, the platform shows abscopal effect, an ability to reach tumors after administration from a distance (subcutaneous or mucosal).

The platform has shown the following characteristics:

1. Tumor-tropism / Cancer-agnostic. Homing to tumor occurred in the absence of a cancer antigen marker (TAA or TSA), and may even work in tumors that are not easily "targetable", such as "cold", lacking cancer markers, heterogeneic or mutating tumors. One oncologist remarked, "This turns "cold" tumors "hot" ".The agents have had effect at distance from tumor site when administered subcutaneously or mucosally. 

 2. Tumor-infiltration + TME counteraction. The agents bear a specialized "universal key" to gain entry into mammalian cell in an active process; no specific  receptor needed. In addition, the agents are able to reprogram tolerogenic cells into a state of immune competence i.e. to overcome cancer-induced immune suppression within the tumor.

3. Intra-cancer delivery of any payload/s. Obligate intracellular microbes, the agents infect cancer cells and replicate, expressing encoded biodrugs. The replication continues as long as there is cancer tissue to infect and/or the TME has not been disabled.  Any agents outside of the TME were naturally cleared in under 10 days.

GattaCo is a Southern California start-up that has developed disruptive new technologies and products solving billion dollar bottlenecks in healthcare. These include its A-PON™ and Pediatric mini-PON™ Kits, which are self-contained, fully-automatic and disposable centrifuge replacement tools. The PON devices are used to extract a precise volume of antibody-rich plasma from a few drops of finger-stick capillary blood so that the plasma can be dispensed into a rapid diagnostic testing platform, such as a rapid COVID-19 antibody test, or into a tube for shipping liquid plasma to a clinical lab for analysis. The mini-PON device eliminates the need for a venipuncture for pediatric blood testing. The availability of liquid plasma for clinical lab processing, collected and processed remotely, greatly simplifies lab workflow compared to dried blood sample processing and provides a more consistent and stable sample for high-sensitivity and high-throughput serological testing. When used in conjunction with rapid antibody tests, the PON devices can provide more consistent, higher-sensitivity and quantitative results compared to the same volume of whole blood, and may allow clinically significant rapid tests to be performed in Point of Care settings.

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For more than 120 years, the Trade Commissioner Service (TCS) has been helping Canadian companies navigate international markets. Our trade commissioners in more than 160 cities worldwide can provide you with key business insights and access to an unbeatable network of international contacts. The TCS provides Canadian businesses and organizations with tailored advice to help them enter new markets outside of Canada.

OROX BioSciences is an early-stage biotech startup involved in discovery/development of small molecules capable of treating fibrosis, inflammation, and oncology.

AnGes is a commercial-stage biopharmaceutical company that focuses on the development and commercialization of gene-based medicines including gene therapy, oligonucleotide drugs and DNA vaccines.
The company's lead product is Collategene for critical limb ischemia (CLI), the severest form of peripheral arterial disease (PAD), for which obtained conditional approval in Japan on March 2019. Collategene is a gene therapy product utilizing therapeutic angiogenesis by hepatocyte growth factor (HGF) gene expression. Our second project is NF-kB decoy oligonucleotide, for which a phase 1b study for low back pain commenced in February 2018 in the US. AnGes also conducting a phase I/II study for DNA vaccine for the treatment of hypertension.
We are also developing a DNA vaccine for COVID-19 which we plan to start Phase 3 from early next year.

ImmunoBiochem has pioneered a proprietary technology to address the challenges of cancer heterogeneity and tumor penetration by biologics in solid tumors with its tumor microenvironment-targeted potentiated antibodies. ImmunoBiochem's biologics are aimed at targets amplified in the secretomes of cancer cells that enable selective and efficacious delivery of payloads in tumor cells, immune cells and tumor-supporting stroma within the tumor microenvironment. ImmunoBiochem is able to deliver novel immunomodulatory payloads to a variety of cell types within the tumor in a highly selective fashion, pioneering a next-generation strategy for the delivery of innate immune system modulators.

Nanovista is a biotechnology company based out of JLABS @ Toronto that is developing technologies to improve the outcomes of cancer surgeries. Nanovista’s lead program, CF800, is a novel imaging agent that enables the real-time visualization of solid tumors during cancer surgery.

Abveris is a Massachusetts-based company that provides industry-leading solutions for therapeutic and reagent antibody developements. We have built a strong reputation for our ability to deliver outstanding science. Based on our proprietary hyperimmune mouse models, DiversimAb mouse, and a Beacon-based single B cell screening platform, we have custom-built gene-to-antibody solutions to support development efforts for therapeutic antibodies against difficult targets such as GPCR, ion channels, glycan targets. Abveris is rapidly expanding its antibody discovery capabilities and geographical presence to work with more emerging biotech to discover therapeutics for novel targets.