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Aposave is the global pharmaceutical and healthcare services division of the Abacus Medicine Group.

The company mission is to assist patients with unmet medical needs get access to innovative new medicines, while assisting the manufacturers to maximise the clinical and commercial potential of their assets.

Our promise to healthcare and pharmaceutical customers is to provide a new generation of healthcare and pharmaceutical services to support their new generation of pharmaceutical products throughout the 2020’s and beyond.

To do this Aposave has developed a market leading range of services focused on providing access to medicines around the world. Working across the lifecycle in partnership with pharmaceutical and biotechnology companies Aposave creates and delivers innovative solutions that ensure patients can get timely access to the medicines they need, whilst helping pharmaceutical and biotechnology companies achieve their clinical and commercial objectives.
Aposave has a range of services to support the efficient running of clinical trials called Clinical Trial Solutions (CTS). This is an area where there are great synergies with our parent company, Abacus Medicine. The Abacus Medicine Group holds over 4500 marketing authorisations, and this provides Aposave with unrivalled access to the medicines required to support the running of clinical trials. In addition, Aposave has developed some unique approaches to minimising wastage of products that have expired or are no longer required for a trial.
Aposave has extensive knowledge and experience in managing the distribution of specialty medicines, and this service line is called Specialty Commercial Distribution (SCD). Higher value, lower volume specialty medicines often do not sit well with the traditional distribution model, and this is where our team of experts develop innovative solutions to help ensure patients have access, while maintaining the commercial requirements of our clients.
Aposave is a strategic partner to the pharmaceutical and biotech industry. Aposave Access Programs (AAP) provide a framework for a partnership where Aposave creates, implements, and manages a program on behalf of a drug manufacturer to provide access to their drug in countries where it is not commercially available. This can be either in the prelaunch, or the post launch stage of the product lifecycle. Each program is designed to meet the specific needs of the manufacturer.
The final service that Aposave provides is very much focussed on the patient, and as such is called Individual Access Requests (IAR). Patients with an unmet medical need often require access to a medicine that is not commercially available in the country where they live. When the customer service team at Aposave receive such a request from a healthcare professional, if we do not already have the product in stock, we find a source of the product and ensure we deliver it, in compliance with appropriate regulations, to the relevant medical establishment ready for the patient to receive treatment.

We are a European oncology start-up developing an entirely novel platform of small molecule drugs to cure currently untreatable cancers.We wholly own a pipeline of molecules that are active via novel mechanisms in cancer and several other therapeutic areas.
The mechanism of action of our lead drug, Ag5, targets cancer cells generating high levels of Reactive Oxygen Species (ROS). High ROS tumours are, in general, untreatable. This group of cancers includes KRAS-mutation driven cancers, which comprise around 30% of all cancer cases, and the worst prognosis group. There is currently no treatment for KRAS mutant cancers, which lead to more than 1 million deaths worldwide every year.
Glioblastoma Multiforme (GBM), the commonest primary brain cancer, is also a high-ROS cancer, despite the absence of mutated KRAS. There have been no new treatment options in GBM for 20 years, and prognosis is poor-averaging 18 months.
We have a follow-on compound and a pipeline of innovative molecules addressing both cancer and non-cancerous conditions.
We are raising a series A round which will allow us to gain clinical proof of concept.

CareAcross is a digital health company focusing on cancer patients, on a global scale.
It is already active in several large countries in 3 continents (Europe, Asia, Americas) including translations and localisation by custom native speakers.
We have been actively investigating the optimal path to China as a very interesting market, but also one that can benefit significantly from our services (both on the patient level, and the industry/academia/research level).

中英生命科学医疗项目合作

Connexin Therapeutics Ltd. is a UK-based biopharmaceutical company specializing in the discovery and development of drugs targeting connexins, initially for the prevention of vision loss and blindness associated with the eye disease known as glaucoma. While there are a variety of glaucoma subtypes, a common hallmark is the progressive loss of vision due to the gradual cell death in the retina and optic nerve triggered by elevated intraocular pressure. Many drugs are available to reduce intraocular pressure, yet none have been shown to directly protect cells in the retina or optic nerve, and hence prevent them from dying. Thus, vision loss inevitably occurs, even in well-treated patients, and severe vision impairment remains common in these patients.
For 20+ years, our scientific co-founder, Dr. Stewart Bloomfield, has researched and published extensively on the connexin-mediated mechanisms by which elevated intraocular pressure causes cell death in the retina and optic nerve, resulting in vision loss. His research has demonstrated three key points:

1. Retinal and optic nerve cell death is mediated by the bystander effect, which, in turn, mediated by a protein called connexin 36; and

2. Inhibition of connexin 36 prevents further loss of vision in glaucoma; and

3. This inhibition can be achieved using a small molecule drug.

Thus, our goal at Connexin Therapeutics is to develop and partner novel compounds which block connexin 36, thereby preserving vision and potentially preventing blindness in patients with glaucoma. Importantly, glaucoma patients with either elevated or normal intraocular pressure will benefit from retinal neuro-protectants, even in the presence of aggressive attempts to reduce intraocular pressure via drugs or surgery. Other ophthalmic diseases which may benefit from connexin inhibition include subtypes of glaucoma (i.e., normotensive glaucoma), retinitis pigmentosa, and the prevention of corneal scarring secondary to eye surgery. These are indications which may be pursued as the company grows.
In addition to our work with connexin 36 in glaucoma, we may have an opportunity to discover and develop a novel connexin 45 inhibitor. Preliminary work from our laboratory suggests that inhibiting connexin 45 has protective benefits in a range of ischemic ophthalmic conditions, such as diabetic retinopathy. Thus, we have the opportunity to advance two programs from the current round of financing into full development or even licensing.
Interest from multinational pharmaceutical companies in novel compounds to treat ophthalmic conditions is extraordinarily high, as these companies recognize that the rapidly aging population, coupled with significant unmet needs and favorable reimbursement policies, all make for attractive licensing opportunities for companies like Connexin Therapeutics. Thus, we anticipate initiating licensing discussions with pharmaceutical companies as novel connexin inhibitors emerge from our efforts.
Connexin Therapeutics raised ~£150,000 in Seed financing in early 2019. These funds are being used to synthesize and test novel small molecules in animal models of glaucoma. These compounds are based on a molecule which has already demonstrated efficacy in mouse models of glaucoma. Thus, these data supplement and extend the work already published.
We are currently raising ~£2,000,000 to optimize our lead compounds. After ~8-10 quarters of work we anticipate having a library of patentable compounds which are highly selective for connexin 36, backed by primate data. We will have a second compound which inhibits connexin 45 for diabetic retinopathy. Future financing rounds will take one or both leads into clinical trials, while also fueling our expansion into other indications with this same mechanism of action.

Deutsche Bank is the largest bank in Germany and one of only 4 Depositary Receipt banks able to list Life Sciences and Medtech companies on US exchanges using ADRs.