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Enosi's lead programs involve novel inhibitors of TNF (tumor necrosis factor), which include severe inflammation associated with viral infections, autoimmune disease, fibrotic diseases, Alzheimer’s, cancer and other diseases. The current TNF inhibitors have important “Black Box” warnings for opportunistic infections, cancer, and cardiovascular events, like stroke. Enosi believes our compounds in development will avoid these limitations of current drugs, be more effective, and will allow expansion into many indications/markets that cannot be approached at the present time by current TNF inhibitors because of their side-effects.

EpicentRx is an immuno-oncology company whose focus is to identify and develop less toxic and more effective immunotherapy-based anti-cancer treatments that are active not only as single agents, but that also sensitize tumors to the cytotoxic effects of chemotherapy, radiation and immune checkpoint blockade. EpicentRx's lead program is among a portfolio of novel dinitroazetidine-based drugs that downregulate CD47 – SIRPα to alter the tumor microenvironment and optimize immune responses as well as normalize the tumor vasculature for better drug and oxygen delivery, and has been tested in several clinical trials including an ongoing Phase 3 study in SCLC. The company is also advancing multiple programs through its smart virus AdAPT platform, including three anti-SARS-CoV-2 vaccines, a TGF-beta "trap" starting Phase 1, and various personalized cancer vaccines that have shown to be effective in both chemotherapy and immune resistant tumors. For more information regarding EpicentRx, go to: http://www.epicentrx.com.

• EpimAb Biotherapeutics is a biopharmaceutical R&D company based in Shanghai creating a pipeline of novel biologics focused around oncology and other disease areas of high value to patients using its a proprietary, and unique technology called FIT-Ig (Fabs-In-Tandem Immunoglobulin). Company’s pioneer product EMB-01 is a bispecific antibody based on FIT-Ig platform targeting EGFR as well as c-MET, currently is in being investigated for treatment of solid tumors in global Phase I/II clinical trial. EpimAb aims to commercialize its FIT-Ig technology as broadly as possible and maximize the number of programs based on the platform. Further information please visit www.epimab.com
• 岸迈生物科技有限公司是一家总部位于上海的生物制药研发公司。公司基于自主研发的FIT-Ig®双特异性抗体平台技术,聚焦于肿瘤IO领域的创新药品开发。公司的先锋产品EMB-01是一种基于FIT-Ig®平台的双特异性抗体,针对EGFR和c-MET靶点,目前正在进行针对实体瘤的全球I/II期临床试验。岸迈生物的目标是尽可能广泛地将其FIT-Ig®技术商业化,并最大限度地拓展基于该平台的新药开发。更多信息,请访问公司官网www.epimab.com。

ExoProTher Medical is an Israeli pre-clinical stage company developing a novel biotherapy for cancer treatment, relevant to all cancers with p53 mutation or inactivation - more than 60% of human cancers. Our technology is unique and disruptive and is fully owned by the company.

The company has been funded by private investors. We are currently working on shaping our next funding round.