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Bi-Specific antibody drug discovery

AEBi was established in the year 2000, and has been managed since then based on the idea that the ability to manipulate and design peptides has vastly superior advantages to many, if not any, existing and trajectory technologies of drug development. This idea is valid today as well.The basic idea is that we do not require a natural lead or a sequence (usually coming from the academia or other research) which are either not strong enough or not specific enough and difficult to manipulate in order to create a drug.
An artificial high complexity pool, representing a broad spectrum of  possibilities, manipulated by our technology, will provide the best possible solution. Such a  solution  will not be hindered or blocked by natural interactions and will be very specific to the problem.
AEBi, a development-stage biopharmaceutical company engaged in discovery and development of therapeutic peptides, has developed a combinatorial biology screening platform technology (IP protected).
The major advantage is that it can be used not only to find binders to known targets, but to select the best functional molecules among them. AEBi's platform is very flexible, exploiting combinatorial biology to discover new and better lead compounds to disease targets.

Our Breakthrough SoAP Platform:
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Our platform provides functional leads to very difficult targets (functional leads - agonist, antagonist, inhibitor, etc.), not merely those that best bind with the target.

Moreover, it allows us to develop drugs to many illnesses, among them CANCER and COVID19, and is expected to transform the drug discovery R&D phase by significantly reducing the attrition rate of new drug candidates.
This Breakthrough technology generates very specific lead compounds with greater functionality and improved pharmacological properties. Such lead Compounds will allow more effective drugs and fewer side effects. The need for such technology is acute and pressing for many reasons. The sole external requirement in the screening process is a Defined Target (usually an illness-related protein).

MuTaTo: our Multiple Targeted Comprehensive Cancer Therapy
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This new cancer treatment is a personalized medicine concept, that can be also turned into a "shelf product". The main principal of it is using multiple targeting peptides connected together with a toxin. The main advantage of it is that it would lower the probability of the targeted cancer cells to develop drug-resistance due to mutations they possess, and at the same time would lower adverse effects due to avidity effect. Each cancer patient would receive a specific drug perfectly suited to his/her cancer, based on the expression profile of receptors on the outer membrane of their cancer cells. This therapy's construct production is easy and rapid. Therefore, the production cost would not be as expensive as with other biological drugs, or other sophisticated cancer treatments.
MuTaTo our Multiple Targeted Safe Cancer Therapy is DIFFERENT and UNIQUE because:
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1- It is EFFECTIVE on almost all types of CANCERS because we will develop a MuTaTo molecule for every type of cancers.
2- it is SAFE on healthy cells and DOESN'T cause any suffering to patients.
3- unlike other cancer therapies that attack cancer from only one or 2 targets at most , MuTaTo is DIFFERENT because it attacks cancer from at least 3 targets so that cancer DOESN'T metastasize nor develop drug resistance.
4- MuTaTo can treat almost all types of cancers even rare one and is effective on all cancer stages even terminal ones.
5- our MuTaTo is so versatile it can be:
a) used as personalized Cancer therapy where each cancer patient would receive a specific drug perfectly suited to his/her cancer, based on the expression profile of receptors on the outer membrane of their cancer cells.
b) or it can be mass produced as a "shelf Product - Oncolytic Drug" to treat different cancers with different indications, so we will have not just one MuTaTo Drug, but a COMPLETE FAMILY OF MuTaTo DRUGS, to treat almost all types and indications of Cancers , from all stages, even rare and Terminal cancers.

Our MUTATO Cancer treatment is PATENTED,
https://patents.google.com/patent/WO2018061004A1/en?inventor=Ilan+morad&oq=Ilan+morad

Our PLATFORM is patented
https://patents.google.com/patent/WO2007010525A3/en?inventor=Ilan+morad&oq=Ilan+morad

Our concept is peer approved and we have proof of concept, and published in the prestigious Cancer Therapy Magazine
https://m.scirp.org/papers/98400

-Chinese Journals have written about our concept including MyBioGate
https://mp.weixin.qq.com/s/NYjbJDgdBOtxsAztKr7wMw
独家回访 | 一年内彻底治愈癌症,炒作还是事实？
徐子宜 Ginger 美柏企业服务
here is one article about us in another journal:
https://www.myzaker.com/article/5f88ec9f32ce40ea2900000a

RA/QA and clinical services consultancy company dedicated to medical devices.
We have been providing services to a wide variety of medical devices in every Class to prepare technical documents for CE certification and FDA authorization.
Services that are sought most are
Compiling or updating Technical Files according to MDR (EU 2017/745) and IVDR (EU 2017/746)
CEP, CER, PMCF Plan, Clinical Trial Protocols
QMS updates
Sterilization Validation, Process Validation, Packaging Validation, Software Validation, etc.
GAP, Mock, Supplier Audits
Medical device registration in 140 countries

Alloy is making a humanized transgenic antibody discovery platform, developed within a large pharmaceutical company, broadly available. Our business model includes unlimited access under royalty free terms. Alloy’s strategic plan is to include additional platforms in the protein engineering space that can be synergistically incorporated into our platform, thereby increasing the value offered to licensees.

AnGes is a commercial-stage biopharmaceutical company that focuses on the development and commercialization of gene-based medicines including gene therapy, oligonucleotide drugs and DNA vaccines.
The company's lead product is Collategene for critical limb ischemia (CLI), the severest form of peripheral arterial disease (PAD), for which obtained conditional approval in Japan on March 2019. Collategene is a gene therapy product utilizing therapeutic angiogenesis by hepatocyte growth factor (HGF) gene expression. Our second project is NF-kB decoy oligonucleotide, for which a phase 1b study for low back pain commenced in February 2018 in the US. AnGes also conducting a phase I/II study for DNA vaccine for the treatment of hypertension.
We are also developing a DNA vaccine for COVID-19 which we plan to start Phase 3 from early next year.

Aposave is the global pharmaceutical and healthcare services division of the Abacus Medicine Group.

The company mission is to assist patients with unmet medical needs get access to innovative new medicines, while assisting the manufacturers to maximise the clinical and commercial potential of their assets.

Our promise to healthcare and pharmaceutical customers is to provide a new generation of healthcare and pharmaceutical services to support their new generation of pharmaceutical products throughout the 2020’s and beyond.

To do this Aposave has developed a market leading range of services focused on providing access to medicines around the world. Working across the lifecycle in partnership with pharmaceutical and biotechnology companies Aposave creates and delivers innovative solutions that ensure patients can get timely access to the medicines they need, whilst helping pharmaceutical and biotechnology companies achieve their clinical and commercial objectives.
Aposave has a range of services to support the efficient running of clinical trials called Clinical Trial Solutions (CTS). This is an area where there are great synergies with our parent company, Abacus Medicine. The Abacus Medicine Group holds over 4500 marketing authorisations, and this provides Aposave with unrivalled access to the medicines required to support the running of clinical trials. In addition, Aposave has developed some unique approaches to minimising wastage of products that have expired or are no longer required for a trial.
Aposave has extensive knowledge and experience in managing the distribution of specialty medicines, and this service line is called Specialty Commercial Distribution (SCD). Higher value, lower volume specialty medicines often do not sit well with the traditional distribution model, and this is where our team of experts develop innovative solutions to help ensure patients have access, while maintaining the commercial requirements of our clients.
Aposave is a strategic partner to the pharmaceutical and biotech industry. Aposave Access Programs (AAP) provide a framework for a partnership where Aposave creates, implements, and manages a program on behalf of a drug manufacturer to provide access to their drug in countries where it is not commercially available. This can be either in the prelaunch, or the post launch stage of the product lifecycle. Each program is designed to meet the specific needs of the manufacturer.
The final service that Aposave provides is very much focussed on the patient, and as such is called Individual Access Requests (IAR). Patients with an unmet medical need often require access to a medicine that is not commercially available in the country where they live. When the customer service team at Aposave receive such a request from a healthcare professional, if we do not already have the product in stock, we find a source of the product and ensure we deliver it, in compliance with appropriate regulations, to the relevant medical establishment ready for the patient to receive treatment.

Bioindustry Park “Silvano Fumero” is an Italian scientific and technological park, specialized in Life Sciences, located in the Piedmont region, near Turin. Bioindustry Park promotes and develops Life Sciences research and innovation by hosting and supporting companies, start-ups and research institutions. Bioindustry Park offers a full range of services aimed at the creation and development of life sciences and health care start-up and spin-off companies not only by providing laboratories and facilities, but also through valuable scientific and business support services. Bioindustry Park “Silvano Fumero” is also the managing company of bioPmed (http://www.biopmed.eu), the Piedmont health care innovation cluster that involves private and public actors in the pharmaceutical, biotech, medtech and eHealth sectors. BioPmed gathers about 100 companies, touching the whole value chain: from research and academic institutions and foundations, to start-ups, SMEs, private and public hospitals and healthcare centers.

Assist Consultation, Assistance, Service
• Identify Distribution Opportunities, Partners, Joint Ventures
• Guidance for Product Registration (SFDA), Regulatory Issues
• Intellectual Property Assessment
• Develop Successful Business Strategy
• Marketing/Analysis
• Manufacturing/Sourcing
• Investment Advisory

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